Michael J Lenardo Selected Research

Autoimmune Lymphoproliferative Syndrome

1/2020	Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease.
3/2014	Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations.
1/2011	Gene defects in the soma: some get it and some don't!
11/2007	Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome.
7/2007	Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib.
4/2006	Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome.
1/2006	Genetic disorders of programmed cell death in the immune system.
9/2002	Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.

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Michael J Lenardo Research Topics

Disease

15	Neoplasms (Cancer) 01/2021 - 12/2005
8	Infections 01/2022 - 05/2002
8	Autoimmune Lymphoproliferative Syndrome 01/2020 - 09/2002
7	Lymphadenopathy 01/2020 - 09/2002
6	Epstein-Barr Virus Infections 01/2022 - 09/2011
6	Inflammation (Inflammations) 01/2020 - 05/2008
5	Lymphoma (Lymphomas) 12/2020 - 03/2009
4	Immune System Diseases (Immune Disorders) 01/2019 - 07/2014
3	Virus Diseases (Viral Diseases) 01/2021 - 12/2003
3	Starvation 05/2011 - 04/2007
2	Viremia 01/2022 - 12/2020
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 10/2011
2	Protein-Losing Enteropathies (Protein-Losing Enteropathy) 01/2021 - 01/2017
2	Thrombosis (Thrombus) 01/2021 - 01/2017
2	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2018 - 01/2018
2	Autoimmune Diseases (Autoimmune Disease) 07/2017 - 07/2002
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 07/2010
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2017 - 11/2011
2	Splenomegaly 03/2014 - 09/2002
1	Vasculitis (Vasculitides) 01/2022
1	Portal Hypertension 01/2021
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 12/2020
1	Infectious Mononucleosis (Glandular Fever) 12/2020
1	Idiopathic CD4-Positive T-Lymphocytopenia (T Lymphocytopenia, Idiopathic CD4 Positive) 01/2020
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2020
1	Fever (Fevers) 01/2020
1	Dysgammaglobulinemia 01/2020
1	Cytopenia 01/2020
1	Liver Diseases (Liver Disease) 01/2020
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 01/2019
1	X-Linked Genetic Diseases 01/2018
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2017
1	Hypersplenism (Anemia, Splenic) 03/2014
1	Sepsis (Septicemia) 03/2014
1	Disease Progression 01/2014
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 11/2012
1	Acquired Immunodeficiency Syndrome (AIDS) 11/2011
1	Crohn Disease (Crohn's Disease) 10/2011
1	Lymphopenia (Lymphocytopenia) 07/2011
1	Diarrhea 04/2011
1	Severe Acute Respiratory Syndrome 01/2010
1	Hepatitis C 07/2009
1	Abdominal Aortic Aneurysm 10/2008
1	Vascular Diseases (Vascular Disease) 10/2008
1	Atherosclerosis 10/2008
1	Aneurysm (Aneurysms) 10/2008

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2003
8	MagnesiumIBA 01/2022 - 07/2011
4	Biological ProductsIBA 11/2020 - 10/2009
4	Phosphotransferases (Kinase)IBA 01/2020 - 08/2006
4	T-Cell Antigen Receptors (T-Cell Receptor)IBA 03/2014 - 04/2006
3	AntigensIBA 11/2020 - 04/2005
3	CaspasesIBA 01/2020 - 12/2003
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 03/2009
3	Sirolimus (Rapamycin)FDA Link 01/2014 - 06/2010
3	CytokinesIBA 03/2011 - 12/2005
3	Caspase 10IBA 11/2007 - 09/2002
3	Fas Ligand Protein (Fas Ligand)IBA 07/2007 - 09/2002
3	Caspase 8 (Caspase-8)IBA 08/2006 - 09/2002
2	GTP Phosphohydrolases (GTPases)IBA 01/2022 - 01/2021
2	Immunoglobulins (Immunoglobulin)IBA 01/2021 - 07/2017
2	Complement System Proteins (Complement)IBA 01/2021 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 03/2014
2	Glycoproteins (Glycoprotein)IBA 01/2020 - 05/2002
2	AutoantibodiesIBA 01/2019 - 11/2011
2	Insulin (Novolin)FDA Link 01/2017 - 11/2011
2	Interleukin-17 (Interleukin 17)IBA 11/2012 - 03/2011
2	Monomeric GTP-Binding ProteinsIBA 01/2010 - 05/2007
2	NF-kappa B (NF-kB)IBA 10/2009 - 03/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2005 - 12/2003
1	Messenger RNA (mRNA)IBA 01/2021
1	LigandsIBA 12/2020
1	NK Cell Lectin-Like Receptor Subfamily KIBA 01/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2017
1	NucleotidesIBA 07/2017
1	MetalsIBA 07/2014
1	Divalent CationsIBA 07/2014
1	CationsIBA 07/2014
1	Alkaline Earth MetalsIBA 07/2014
1	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2014
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 03/2014
1	Myelin-Oligodendrocyte GlycoproteinIBA 11/2012
1	Interleukin-15 (Interleukin 15)IBA 11/2012
1	AntibodiesIBA 11/2011
1	Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA 10/2011
1	Leucine (L-Leucine)FDA Link 10/2011
1	TOR Serine-Threonine KinasesIBA 05/2011
1	Death Domain ReceptorsIBA 01/2011
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 07/2010
1	ADP-Ribosylation Factor 1IBA 01/2010
1	Casein Kinases (Casein Kinase)IBA 03/2009
1	Antigen Receptors (Antigen Receptor)IBA 03/2009
1	Nitric Oxide Synthase (NO Synthase)IBA 10/2008
1	Apolipoproteins E (ApoE)IBA 10/2008
1	ApelinIBA 10/2008

Therapy/Procedure

4	Therapeutics 11/2020 - 01/2017
4	Immunotherapy 11/2020 - 01/2016
2	Hematopoietic Stem Cell Transplantation 12/2020 - 12/2015
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2021
1	Splenectomy 03/2014